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Premature Atrial Contractions Management

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Premature Atrial Contractions Management

Premature Atrial Contractions Management

Admin
Nov 25, 2023

Premature atrial beats, also known as extrasystolic or early heartbeats, are initiated before regular beats or ectopic heartbeats that may originate from any atrial region. Premature atrial contraction (PAC) may be considered a common normal heart condition that may occasionally occur in healthy individuals and is induced by environmental factors such as stress, caffeine intake, smoking, fatigue, and dehydration. However, they frequently occur in heart disease patients. In addition, they may participate in Supraventricular Tachyarrhythmia.

A premature atrial contraction diagnosis is confirmed by electrocardiogram, Holter monitor, or stress tests. Even though they are only managed if they are associated with clinical symptoms such as dizziness, palpitations that result from the ionotropic effect and prolonged ventricular filling time, or skipped heartbeats when the premature atrial beat is not fully conducted or ventricular filling is inadequate.

Nonpharmacological; lifestyle Management

Any predisposing factor that is associated with Premature Atrial contractions and their related symptoms must be avoided.

  • Emotional stress must be controlled and avoided as much as possible.
  • Caffeine intake must be reduced or avoided.
  • Smoking cessation is recommended.
  • Alcohol intake must be minimized.
  • Obesity management and weight reduction are encouraged.
  • Physical activity is associated with better outcomes. 

Managing Comorbidities

Premature atrial contractions may be more prevalent in patients with heart diseases, which may affect atrial structure and pressure. So, the following medical disorders must be appropriately managed and controlled:

  • Uncontrolled Hypertension.
  • Acute myocardial infarction.
  • Hypertrophic Cardiomyopathy.
  • Valvular Heart diseases, including Mitral valve stenosis.
  • Aging-induced Atrial remodeling.
  • Atrial Amyloidosis. 
  • Uncontrolled Hyperthyroidism.
  • Obstructive Sleep apnea.

Pharmacological therapy

Antiarrhythmic medications may be indicated if Premature Atrial contractions are associated with irregular heart rhythm and frequent symptoms that are not adequately controlled with predisposing factor elimination.

  • Beta Blockers are recommended to control associated symptoms by reducing heart rate, which may be elevated due to high sympathetic tone. However, it may not be adequately effective in some patients.
    • Metoprolol initial dose: 25mg orally twice daily, titrated as needed
  • Antiarrhythmic medications in Class Ia: Quinidine, Disopyramide, and Procainamide; Class Ic; Propafenone and Flecainide; and Class III; Amiodarone, Dronedarone, Ibutilide, Dofetilide, and Sotalol can control Premature Atrial contractions and prevent the development of associated Supraventricular Tachyarrhythmia. On the other hand, these antiarrhythmic medications are associated with pro-arrhythmia risk.

Some Antiarrhythmic medications may not be effective. Other medications used may worsen premature atrial contraction symptoms. 

  • Calcium channel blockers, digoxin, and Class Ib antiarrhythmic medications, such as lidocaine, are not effective in premature atrial contraction management. 
  • Bronchodilators used in the management of chronic obstructive pulmonary disease (COPD) may participate in premature atrial contractions, so patients on bronchodilators must be closely monitored.
  • Theophylline, a methylxanthine compound that is used in Asthma management, should be avoided

Catheter Ablation

It is recommended to manage Premature Atrial contractions that are not raised in the pulmonary vein, are not adequately controlled with medical therapies, and lead to the development of Atrial Fibrillation or are associated with high risk for Cardiomyopathy. 

In this procedure, a catheter is inserted and guided up to the heart under X-ray visualization with the use of contract media, while the catheter is connected to an electrical impulse sensor and recorder to detect Atrial Premature contractions, Radiofrequency heat energy or cold cryoablation energy is then directed into cardiac tissues where abnormal electrical heart signals are detected to prevent their conduction and consequent arrhythmia.

Pulmonary vein Isolation

It is recommended if premature atrial contractions are associated with pulmonary veins. It is a surgical procedure that is usually performed under light sedation or general anesthesia and is considered a type of cardiac ablation that targets the left atrium area that is connected to the four pulmonary veins.

References

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